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KMID : 0352419920110030367
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Keimyung Medical Journal
1992 Volume.11 No. 3 p.367 ~ p.380
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α-D- Mannosidase, β-D- Mannosidase, α -D - Glucosidase and β- D - Glucosidase Activities in Regenerating Rat Liver
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Abstract
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A study was made on the changes of -D-mannosidase, -D-mannosidase, -D-glucosidase and -D-glucosidase activities in regenerating rat liver.
The cytosolic, lysosomal, Golgi and mecrosomal -D-mannosidase, lysosomal -D-mannosidase, lysosomal -D-glucosidase, cytosolic broad specificity -D-glucosidase and lysosomal acid -D-glucosidase activities were determined in the regenerating liver after 70% (median and left lateral lobers) partial hepatectomy in rats over a period of ten days. The activities of cytolic, lysosomal and Golgi -D-mannosidase, lysosomal -D-mannosidase sidase and lysosomal -D-glucosidase in the serum were measured together with the above determination of hepatic glycosidases.
The activities of cytotoslic -D-mannosidase of the serum and regenerating liver decreased slightly between the second and the third days after partial hepatectomy.
The activity of Golig -D-mannosidase in the regenerating liver decreased significantly on the third day after partial hepatectomy. However, no significant change in the serum Golgi -D-mannosidase activity was noted throughout the experiments.
The microsomal -D-mannosidase activity in the regenerating liver had a slight diminution between the second and the sixth days after partial hepatectomy.
The lysosomal -D-mannosidase activity in the regenerating liver significantly decreased on the second day after partial hepatectomy. That of serum lysosomal -D-mannosidase showed a slight decrease from the second day after operation.
The lysosoml -D-glucosidase activity in the regenerating liver showed a slight decrease between the first and the third days after partial hepatectomy, while the serum lysosomal -D-glucosidase activity did not change.
The cytosolic broad-specificity -D-glucosidase activity in the regenerating liver slightly decerased between the second and the third days after partial hepatectomy. The lysosomal acid -D-glucosidase activity in the regenerating liver considerably decreased between the first and the third days after operation.
Summarizing the results, -D-mannosidase, -D-mannosidase, -D-glucosidase and -D-glucosidase in the regenerating liver thought to be the enzymes decreasing their activities in the regenerating stage.
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